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KMID : 0370220140580010053
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Yakhak Hoeji
2014 Volume.58 No. 1 p.53 ~ p.57
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Quantitative-Structure Activity Relationship (QSAR) Model for Abuse-liability Evaluation of Designer Drugs
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Yun Jae-Suk
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Abstract
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In recent, the abuse of newly-emerging psychoactive drugs, (’designer drugs’) is a rapidly increasing problem in Korean society. Quantitative-structure activity relationship (QSAR) is an alternative method to predict bioactivities of new abused compounds. In this study, cathinone-related new designer drugs, 4-methylbuphedrone and 4-methoxy-N,N-dimethylcathinone were tested for prediction of the bioactivity with QSAR model. The bioactivity of 4-methylbuphedrone and 4-methoxy-N,N-dimethylcathinone was similar to those of methylone. These results suggest that the prediction with QSAR model may provide scientific evidences for regulatory decision.
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KEYWORD
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designer drug, QSAR, bioactivity, regulation, addiction
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